Consequently, the JAK2-associated cytokines including IL-2, IL-5, IL-6, IL-12, IL-13, and IFN-γ were detected, and although IL-2 and IL-12 concentrations were non-detectable in all groups; IL-5, IL-6, IL-13, and IFN-γ levels were markedly higher in severe CRSwNP than in the control groups. The gene discussed is IFNG; the disease is chronic rhinosinusitis with nasal polyps.