An intriguing recent observation [9,10] was the induction of p53 specific cytotoxic T lymphocytes upon incubation of PBMC’s from hepatocellular carcinoma and pancreatic adenocarcinoma A24-carrying patients with a synthetic p53-derived peptide (residues 161–169 of p53, sequence AIYKQSQHM, hereafter referred to as p161). The gene discussed is TP53; the disease is hepatocellular carcinoma.