Several studies have proposed tetracyclines and derivatives, such as doxycycline and minocycline, as neuroprotector antibiotics through several mechanisms: their anti-inflammatory properties [41]; their ability to protect dopaminergic neurons in the substantia nigra [185]; the fact that they regulate the glial response in induced PD animal models [186]; their capacity to both inhibit fibril formation of amyloid beta (Aβ) [187], prion protein (PrP) [188,189], β-microglobulin [190] and aSyn [191] and to block amyloid size and aggregation [192,193]. Here, PRNP is linked to Parkinson disease.