Furthermore, plasma OPN levels predicted death within four years of follow-up in these patients (382 ng/mL for control subjects versus 532 ng/mL for patients with HF and 479 ng/mL for the New York Heart Association (NYHA) class I/II versus 672 ng/mL for NYHA class III/IV) [90]. The gene discussed is SPP1; the disease is hydrops fetalis.