In a model triple-negative breast cancer cell line MDA-MB-231, the peptide antagonist Allo-aca at 1 pM–100 nM concentrations proved to antagonize the mitogenic effects of leptin in a concentration-dependent manner without interfering with MDA-MB-231 proliferation in the absence of native leptin [119,120]. This evidence concerns the gene LEP and triple-negative breast carcinoma.