Furthermore, the impact of EPLIN-α overexpression in HECV cells was also tested, using tubule formation assays and through the co-injection of either overexpressed EPLIN-α or plasmid control HECV cells with MDA-MB-231 cells in mice, demonstrating a role in inhibiting tubulelike structure formation in in vitro and in vivo tumour development [41]. This evidence concerns the gene LIMA1 and neoplasm.