A later study subsequently demonstrated the capacity of EGF-induced ERK to phosphorylate human EPLIN in prostate cancer cells on Ser362 and Ser604, which pair to Ser360 and Ser602 in mouse EPLIN, leading to EPLIN ubiquitination and degradation and downregulation of E-cadherin, an essential marker of EMT progression [11]. This evidence concerns the gene LIMA1 and prostate cancer.