BDNF and nervous system disorder: A review of the current literature supports that the idea that the effectiveness of clozapine may be due to similarities in the mechanism to ECT in the following areas: epileptiform activity and EEG changes, increased neuroplasticity and levels of BDNF, effects on the glutamate/GABA imbalance that occurs in a variety of psychiatric and neurologic disorders, and influence on neuron–glia interactions by a reduction in inflammation through effects on cytokine release from glia.