The results of the analysis indicate that the NQO1 609C > T polymorphism was significantly associated with the risk of colorectal cancer (total OR = 1.30, 95% CI = 1.07–1.59) for CT vs. CC, 1.64 (1.15–2.33) for TT vs. CC, 1.34 (1.10–1.64) for TT/CT vs. CC, and 1.43 (1.10–1.87) for TT vs. CT/CC). This evidence concerns the gene NQO1 and colorectal cancer.