In conclusion, our study demonstrated an increased risk for developing colorectal cancer in patients with the TT genotype of the NQO 609C > T polymorphism.Hence, it can be concluded that the NQO1 polymorphism is related to the risk of colorectal cancer and the process of metastasis in the Polish population.Future studies should be conducted in large-scale cohorts and should take into account the interactions of the genotype withotherfactorsconsidered(e.g., diet, tobacco smoke exposure). This evidence concerns the gene NQO1 and colorectal cancer.