Furthermore, the sialic acid-binding immunoglobulin-type lectins (SIGLECs), mainly SIGLEC7 and others, such as SIGLEC5, SIGLEC9, and SIGLEC11, have been associated with severe cases of COVID-19, suggesting the importance of these receptors that could be regulated by the enhanced sialic acid affinity of the S protein [32,37]. The gene discussed is PROS1; the disease is COVID-19.