It may be therefore hypothesized that stiffening of the matrix leads to TRPV2 translocation to the plasma membrane in a PI3K/Rac1-dependent manner and that TRPV2-mediated Ca2+- influx plays a role in MMP production through yet unknown mechanism, at least in prostate and ovarian cancer models [226,259,285]. Here, TRPV2 is linked to ovarian carcinoma.