HNRNPA2B1 and amyotrophic lateral sclerosis: Karyopherin-β2 (Kap-β2) is a nuclear import receptor that binds to and prevents the aggregation of RBPs including FUS, TAF15, EWSR1, hnRNPA1, and hnRNPA2, many of which accumulate in the cytoplasm in ALS and related disorders [32].