APP and Alzheimer disease: Furthermore, several clock-controlled genes involved in insulin signaling and mitochondrial function are also modulated by NOB, including Igf1, Igl1r, Glut1, Insr, Irs1, Ucp2, Ucp4, and Cpt1c. These results are, on the one hand, consistent with prior studies showing their altered expression in AD models, particularly APP/PS1 [64,65,66].