An aberrant elevation of different inflammatory mediators, including IL-1β, IL-1RA, IL-8, IL-9, IL-7, IL-10, fibroblast growth factor (FGF), granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte-colony-stimulating factor (G-CSF), IFNγ, interferon-γ-inducible protein (IP10), monocyte chemoattractant protein (MCP1), platelet-derived growth factor (PDGF), macrophage, inflammatory protein 1 alpha (MIP1A), vascular endothelial growth factor (VEGF) and tumor necrosis factor (TNFα), contribute to the severity of COVID-19 [27,33]. The gene discussed is CCL3; the disease is COVID-19.