Since VEGF is considered as a major pathogenic factor and therapeutic target for the breakdown of BRBs in DR, AMD, and ROP, and other hypoxic retinal vascular disorders [8,9,10,11], revealing if VEGF is a direct functional regulator of retinal neurons is not only important to addressing a major knowledge gap in retinal neurobiology but is also critical to the understanding of the therapeutic effect(s) of anti-VEGF drugs. The gene discussed is VEGFA; the disease is retinopathy of prematurity.