BDE proteins that decreased in AD were Aβ42, APP, t-tau, NRGN, synaptophysin, synaptotagmin, synaptopodin, SNAP-25, AMPA4 receptor, NPTX2, NLGN1, NRXN2, P-S9-synapsin 1, synapsin 1, MOG, GDNF, FGF-2, FGF-13, HGF, IGF-1, p-Y-IRS-1, HSP70, REST, GFAP, GluSyn, CD81, GAP43, and Septin-8. The gene discussed is REST; the disease is Alzheimer disease.