PON1 and nervous system disorder: The study investigated the influence of the least efficient isoforms of PON1 genetic polymorphisms in humans and Pon1−/− genotype in mice and found that both genetic modifications induce changes in the plasma proteome that affect biological networks involving proteins participating in lipoprotein metabolism, in CVD in neurological diseases, in immune response, inflammatory response, in cell-to-cell signaling, and immune-cell trafficking.