Overall, the augmentation of the content of IOP-increasing and cytotoxic mediators PAF and 12,13-DiHOME, together with oxidative stress-related oxylipins HODEs/KODEs, represent a part of the pathophysiological picture of POAG manifesting in the signaling lipidome of AH. The gene discussed is PCLAF; the disease is open-angle glaucoma.