Recently, we showed that the global knockout of nuclear factor erythroid 2-related factor 2 and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (NFE2L2/PGC-1α), the master regulators of antioxidant production and mitochondrial biogenesis, led to disturbed autophagy, an accumulation of drusen-like deposits, and the infiltration of Iba-1 positive immune cells mimicking clinical features of the dry AMD phenotype [24]. Here, PPARGC1A is linked to dry age related macular degeneration.