To address this study, several pro-oxidant enzymes (XO) and oxidized compounds (GSSG), antioxidants enzyme activities and compounds (SOD, CAT, GPx and GSH), lipid oxidative damage (MDA) and inflammatory markers were investigated in both plasma and/or isolated PMNs and MNs cells from NDD-CKD, HD and PD patients and healthy subjects. Here, SOD1 is linked to Neurodevelopmental delay.