In addition to the above findings, a hypothetical method that adds to the therapeutic possibilities of melatonin to moderate the inappropriate inflammatory response of COVID-19 is the control of Nuclear Factor (erythroid-derived 2)-like 2 (NRf2), a pivotal regulator of antioxidant responses that induce phase-II antioxidant enzymes [29]. Here, NFE2L2 is linked to COVID-19.