In particular, NFκB is the major transcription factor activated in the acute inflammatory phase of sepsis that upregulates the pro-inflammatory cytokines and effectors (i.e., TNFα, IL-1β, IL-6, iNOS, etc.)that are suppressed in tolerized innate immune cells, and it has also been shown to reprogram the chromatin (i.e., DNA and histone) methylome by regulating expression of certain histone methylases. This evidence concerns the gene NOS2 and Sepsis.