Sinensetin, a polymethoxyflavone, induced the AMPK/mTOR pathway and subsequent autophagic cell death in HepG2 p53 wild type cells, and it induced apoptotic cell death in a p53-null cell line (Hep3B), suggesting sinensetin has great potential in the development of strategies for the treatment of apoptosis-resistant hepatocellular carcinoma [59]. The gene discussed is PRKAA1; the disease is hepatocellular carcinoma.