Importantly, recent genetic discoveries have supported the relevance of mitochondria in PD pathology, once multiple PD-associated genes encode proteins that are relevant to mitochondrial homeostasis [69], such as genes encoding for presynaptic protein α-synuclein, E3 ubiquitin ligase Parkin, PTEN-induced putative kinase 1 (PINK1), protein deglycase DJ-1, leucine-rich repeat kinase 2 (LRRK2), ATPase 13A2 and vacuolar protein sorting-associated protein 35 [69,70]. The gene discussed is VPS35; the disease is Parkinson disease.