They determined SOD and GPX activity and MDA levels in plasma, erythrocytes, and skin biopsies in two groups; 20 psoriatic patients were treated with oral PTU 100 mg three times daily, and 10 patients were treated with PTU plus 25 μg of thyroxine daily (to prevent possible hypothyroidism, which can be induced by PTU) for 8 weeks. The gene discussed is SOD1; the disease is hypothyroidism.