Icariin exerts a protective role in AD counteracting oxidative stress phenomena [87] and, most importantly, prevents memory deficits in Aβ-injected rats [88] by rescuing the BDNF signaling pathway and reverting decreases in postsynaptic density protein (PSD-95) and the phosphorylated form of cAMP response element-binding protein (p-CREB) levels. Here, BDNF is linked to Alzheimer disease.