IL6 and ischemic stroke: An in vivo study conducted by Yap et al. using an animal model of ischemic stroke [57] demonstrated that astrocytes are able to secrete Interleukin 6 (IL-6) with consequent inhibition of T helper 1 cell differentiation and the promotion of regulatory T cells (Tregs) with an increase in TGF-β1 levels contributing to the effect of hyperforin on neuroangiogenesis and functional recovery.