CCL2 and metabolic dysfunction-associated steatohepatitis: It has been reported that supplementation with green tea extract (2% in diet, 8 weeks) could increase NRF2 and NQO1 mRNA expressions, and reduce hepatic steatosis, lipid uptake, lipogenic gene expression, lipid peroxidation, and NF-κB-dependent NASH; while in NRF2-null mice, green tea extract lowered NF-κB phosphorylation and TNF-α and monocyte chemoattractant protein-1 (MCP-1) mRNA in a NRF2-independent manner, without improving the hepatic antioxidants α-tocopherol, ascorbic acid, and uric acid [121].