In a study with nuclear SREBP-1c transgenic mice, EGCG (0.05% and 0.1% in drinking water, 12 weeks) was shown to reduce insulin resistance, oxidative stress, liver inflammation, and related liver injury, owing to the decreased expressions of pNF-κB, pAkt, and pIKK-β (inhibitor of nuclear factor kappa-B kinase) [134]. The gene discussed is SREBF1; the disease is Insulin resistance.