In NAFLD, NF-κB can be activated in a redox-dependent manner by oxidative stress, and blockage of NF-κB activation inhibits the release of proinflammatory cytokines, including TNF-α, IL-1β, IL-6, and MCP-1 [134,135,136]. This evidence concerns the gene NFKB1 and metabolic dysfunction-associated steatotic liver disease.