In another study, it was also reported that the beneficial effect of green tea against fat accumulation in NAFLD could be attributed to the downregulation of hepatic miR-34a, with increases in its mRNA targets Sirt1, Pparα, and Insig2, as well as the upregulation of hepatic miR-194, with decreases in its target genes Hmgcs/Apoa5 [133]. The gene discussed is SIRT1; the disease is metabolic dysfunction-associated steatotic liver disease.