The potential mechanisms of action may involve the improvements in oxidative stress, metabolism dysfunction, inflammation cascades, fibrotic response, and HCC tumorigenesis, in which the modulations in NRF2, AMPK, SIRT1, NF-κB, TLR4/MYD88, TGF-β/SMAD, and PI3K/Akt/FoxO1 signaling pathways are essential. Here, NFE2L2 is linked to hepatocellular carcinoma.