Green tea and EGCG have been shown to improve insulin resistance, lipid absorption, lipid metabolism, and hepatic lipid accumulation, thus exerting beneficial effects against NAFLD, among these actions the upregulations in AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1) have been highlighted [124,125,126,127,128]. The gene discussed is SIRT1; the disease is metabolic dysfunction-associated steatotic liver disease.