In C57BL/6 mice fed with HFD, green tea extract supplementation (30, 60, and 120 mg/kg BW, daily, 12 weeks) was observed to reduce body weight gain, prevent hepatic fat accumulation, decrease hypertriglyceridemia and hyperglycemia, and improve insulin resistance, which might involve the upregulation of SIRT1, and AMPK followed with the downregulation of enzymes related to de novo lipogenesis [129]. Here, SIRT1 is linked to Insulin resistance.