The mechanisms may include, not only alleviating oxidative stress, but also improving lipid metabolism, inflammation cascades, fibrotic response, and HCC tumorigenesis, in which the regulations in the NRF2, AMPK, SIRT1, NF-κB, TLR4/MYD88, TGF-β/SMAD, and PI3K/Akt/FoxO1 pathways are highlighted. Here, TLR4 is linked to hepatocellular carcinoma.