NRF2 can also alleviate NASH through multiple mechanisms, including regulating the expressions of genes regarding pro-inflammatory response and lipid metabolism (e.g., lipogenic and cholesterogenic pathways), and mitigating oxidative stress during NASH by improving redox status concerning glutathione biosynthesis and the expressions of antioxidant enzymes (e.g., NADPH:quinone oxidoreductase 1/NQO1, SOD, and GPX) [121]. The gene discussed is NFE2L2; the disease is metabolic dysfunction-associated steatohepatitis.