Microglial activation and the increased synthesis of phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) induced by nerve injury in the spinal cord and several brain regions provoke central sensitization, thus contributing to the development of anxiety- and/or depressive-like behaviors associated with chronic pain both in animals [14,15] and patients [16]. The gene discussed is AKT1; the disease is Anxiety.