Interestingly, DADS and GYY4137 both avoided the decreased expression of HO-1 and maintained the elevated protein levels of NQO1 and GSTM1 in the AMG, revealing that the potent antioxidant actions of these compounds might also take part in the attenuation of the anxiety- and depressive-like behaviors induced by both compounds during neuropathic pain. This evidence concerns the gene HMOX1 and Anxiety.