The focus of this paper will be COVID-19 sensing mechanism platforms for different biomarker detection, including Nucleic Acid Amplification for Viral RNA, Antigen Testing Nucleocapsid (N), Spike (S), Protein and Serological Test for antibodies (Immunoglobin) IgA, IgM, IgG and Interleukin (IL-6) inflammatory biomarkers. Here, IL6 is linked to COVID-19.