Furthermore, we revealed that genes regulating or co-expressed with HRR genes are members of the E2F family (E2F8, E2F2, and E2F3), known as cell cycle regulators [34]; PRDM9, related to the process of meiosis and responsible for directing the positions of HRR [35]; CENPA, involved in accurate chromosome segregation [36]; and TGIF, reported to be over-expressed among ovarian cancer cell lines [37]. The gene discussed is E2F3; the disease is ovarian cancer.