BRCA1 and breast cancer: In BRCA1 families, we found no significant relation between the number of women with EO-BC diagnosed between age 31 and 35 and the number with VEO-BC in the family (p = 0.87)—or between the number of women with EO-OC diagnosed between age 41 and 45 and the number of women with VEO-OC in the family (p = 0.45).