In total, 78 of the 448 (17.4%) families had at least one VEO cancer case (BC and/or OC): 15% of BRCA1 families included a VEO-BC case and 8% a VEO-OC case, with 9% and 2%, respectively, for BRCA2 families (Figure 1). This evidence concerns the gene BRCA2 and breast cancer.