According to the observation that PI3K mediates oncogenic signaling in Ras-WT cancers, Molina-Arcas and colleagues showed that PI3K is critical for survival of both K-Ras mutant and K-Ras WT NSCLC cells, as PI3K inhibition induced loss of cell viability irrespective of the genotype [167]. The gene discussed is PIK3CA; the disease is non-small cell lung carcinoma.