PTEN and cancer: Analysis of different genes with driver mutations that were linked to the regulation of metabolic pathways in K-Ras-driven cancers, such as Pik3ca [49], KMT2D [193], PTEN [194], and IDH1 [195], suggested a theoretical broader transcriptional and signaling circuit coordinated by Ras together with p110α, NF1, and PTEN for the tight regulation of metabolic pathways [188].