PIK3CA and cancer: Additional supporting evidence of the role of PI3K as a mediator of Ras-induced EMT was obtained in esophageal cancer cells, where depletion of Ras-GAP SH3 domain binding protein (G3BP1, a protein that modulate the Ras signaling pathway via interacting with the SH3 domain of RasGAP and found overexpressed in some cancers [209,210,211]) represses invasion and migration potential via EMT suppression.