Tumor cells bearing Ras mutations can promote tumor-associated angiogenesis through other mechanisms apart of VEGF secretion, such as secretion of different proinflammatory, angiogenic cytokines, such as IL-8 [302,303,304,305], IL-6, and GRO1 (also known as CXC Motif Chemokine Ligand 1, CXCL1) [306] or repression of antiangiogenic factors such as thrombospondin-1 (TSP-1) and TSP-2 [307,308]. Here, THBS2 is linked to neoplasm.