Non-invasive skin imaging performed with reflectance confocal microscopy (RCM) and optical coherence tomography (OCT), enabling in vivo evaluation of different layers of the skin, revealed a different dermal microenvironment in photoexposed skin of MC1R RHC variants carriers as compared to wild-type (WT) [133], suggesting a correlation between photoaging (aging related to UV exposure) in MC1R variant subjects and increased susceptibility to skin cancers [134]. The gene discussed is MC1R; the disease is skin neoplasm.