The only evidence comes from Liboutet et al. who reported the P1315L mutation frequency in PTCH (Protein Patched Homolog 1, component of the hedgehog signaling pathway) not to be significantly different between BCC patients carrying a MC1R variant and those that do not carry one, suggesting an independent effect of both genes on BCC risk [199]. This evidence concerns the gene PTCH1 and skin basal cell carcinoma.