In a study of 220 individuals (111 at high risk and 109 at low risk of BCC and SCC) in Queensland (area of high UVR), the prevalence of NMSCs was associated with the presence of MC1R RHC variant alleles R151C, R160W and D294H, whereas V60L, V92M and R163Q had minimal impact on BCC and SCC risk [167]. Here, MC1R is linked to skin basal cell carcinoma.