The phenotypes arising from NME7 deficiency range from situs inversus was reported in two siblings from a consanguineous family [14], through situs inversus, hydrocephalus and excessive nasal exsudates in mice [15,16] to situs inversus, sterility and massive hydrocephalus leading to premature death in rats [17]. This evidence concerns the gene NME7 and Hydrocephalus.