The stimuli contributing to the transformation of pancreatic stellate cells might be related to the unfavorable environment of obesity and glucose intolerance observed in Nme7+/− male rats as pancreatic islet fibrosis has also been observed in other rat diabetic models, including non-obese Goto–Kakizaki rats [31] or in mildly obese Otsuka Long–Evans Tokushima fatty rats [32]. This evidence concerns the gene NME7 and Glucose intolerance.