It is also known that CX26 and CX30 can form functional heterotypic/heteromeric gap junction channels, with digenic Cx26 and Cx30 mutations impairing heterozygous coupling of Cx26 and Cx30 in the lateral cochlear wall, which leads to reductions in the endocochlear potential followed by hearing loss [21]. Here, GJB6 is linked to hearing loss disorder.