Moreover, as liver cancer is characterized by a global DNA hypomethylation [147] atypical irregular nuclear structure [148], changes in nuclear size [149], and progenitor-like features [150,151], it is possible that the high levels of UHRF1 in cancer cells function as a dominant negative, blocking DNA methylation and deposition of other heterochromatin marks, reverting the nuclear morphology and function to a progenitor-like state [152,153]. Here, UHRF1 is linked to liver cancer.