Other variables can influence CDKN2A mutation incidence, and one of these is the presence of atypical moles, like in FAMMM syndrome, which has been linked to CDKN2A-carrier status, since family relatives with this syndrome seem to have a three-fold risk of carrying a germline variant [40,41]. This evidence concerns the gene CDKN2A and familial atypical multiple mole melanoma syndrome.