CDKN2A and melanoma: Overall, in the general population, epidemiological studies reported that a high number of nevi (>100) increases the risk of melanoma more than a positive family history (RR = 6.89; 95% CI: 4.63–10.25 vs. 1.74; 95% CI: 1.41–2.14, respectively) [5,13] and more so than when harboring a constitutive pathogenic variant in the high-penetrance CDKN2A gene (RR = 4.3; 95% CI: 2.4–7.7) [43].