After POT1, ACD (ACD Shelterin Complex Subunit and Telomerase Recruitment Factor in 16q22), and TERF2IP (TERF2 Interacting Protein in 16q23), shelterin genes were also recently linked to melanoma predisposition and other cancers, even if germline mutations have only been reported in six and four families, respectively [37]. The gene discussed is TERF2IP; the disease is cancer.