In accordance with this fundamental regulatory role, CdLS cell lines do not display abnormalities in sister chromatid cohesion [20,21] but rather in genes and proteins expression and production [22,23,24,25,26], suggesting that CdLS etiopathology is due to altered transcriptional regulation derived from an impaired function of the cohesin complex in 3D chromatin organization. The gene discussed is NIPBL; the disease is Cornelia de Lange syndrome.