PITX1 and arthrogryposis: There is a possibility FBN2, a gene known to cause Beals syndrome (a form of distal arthrogryposis with scoliosis), was the only gene responsible for the AMC-SC phenotype; and there is a possibility of some type of additive effect between monoallelic FBN2, MEGF10, and PITX1 resulting in an arthgrogrypotic phenotype.