Although the vast majority of cases are caused by loss-of-function variants in SCN1A [64], other genes have also been reported to cause DS, including SCN2A, SCN8A, SCN9A, SCN1B, PCDH19, GABRA1, GABRG2, STXBP1, HCN1, CHD2, and KCNA2 [64] (Table 1). This evidence concerns the gene SCN1A and Dravet syndrome.