Based on previously estimated population frequencies of BRCA1 and BRCA2 mutations, it was estimated that BRCA1 mutations confer a relative risk of prostate cancer of approximately 3.7-fold and 8.6-fold, which translates to an 8.6% and 15% cumulative risk by age 65 years [71,75,76]. Here, BRCA2 is linked to prostate carcinoma.