BRCA1 and endometrial cancer: Recently, in a prospective cohort study of BRCA carriers who received only RRSO, not hysterectomy, endometrial cancer developed in eight patients in a median follow-up of 5.1 years, with no apparent increased risk after RRSO, on the other hand, BRCA1 carriers had an increased risk of endometrial serous adenocarcinoma [92].