Of these haploinsufficiency sensitive genes, 60 genes (23 deleted genes and 37 breakpoint genes) show expression in developing human heart, with 20 genes (9 deleted genes (including one recurrent gene) and 11 breakpoint genes) (ARFGEF2, AUTS2, CHAMP1, CHD8, CYFIP1 (2X), FERMT2, ITCH, KMT2C, MAPK3, MAZ, MYH11, NASP, NPAS2, PIK3C3, PKNOX1, TIA1, TJP1, TRIM28, ZBTB21) having a function that can be related to heart development or CHD pathogenesis. The gene discussed is ZBTB21; the disease is coronary artery disorder.