Of these haploinsufficiency sensitive genes, 60 genes (23 deleted genes and 37 breakpoint genes) show expression in developing human heart, with 20 genes (9 deleted genes (including one recurrent gene) and 11 breakpoint genes) (ARFGEF2, AUTS2, CHAMP1, CHD8, CYFIP1 (2X), FERMT2, ITCH, KMT2C, MAPK3, MAZ, MYH11, NASP, NPAS2, PIK3C3, PKNOX1, TIA1, TJP1, TRIM28, ZBTB21) having a function that can be related to heart development or CHD pathogenesis. This evidence concerns the gene ARFGEF2 and coronary artery disorder.