Evaluation of the protein-coding gene content, based on dosage sensitivity, expression during heart development, and gene function, yielded 19 candidate CHD genes: ARFGEF2, AUTS2, CHAMP1, CHD8, CYFIP1, FERMT2, ITCH, KMT2C, MAPK3, MAZ, MYH11, NASP, NPAS2, PIK3C3, PKNOX1, TIA1, TJP1, TRIM28, ZBTB21. At this time, an exhaustive literature search could not provide conclusive evidence for a certain (causal) relationship of these genes with CHD. The gene discussed is ARFGEF2; the disease is coronary artery disorder.