Taken together, ZEB2-co-controlled astrocyte activation and reactive gliosis, including in a context of multicellular responses (including microglia; [188]) to nervous system damage and disease, is an exciting new ZEB2 research line to explore in mouse and zebrafish models for (repetitive) injuries and pathologies of the brain [189], spinal cord [190], retina [191] and ENS [192,193], and perhaps, more speculative, also in blood vessel disease caused by endothelial dysfunction, e.g., in the brain and in neuroretinal degeneration [194]. The gene discussed is ZEB2; the disease is endothelial dysfunction.