ZEB1 and congenital T-cell immunodeficiency: Their homozygous Zeb1-null(LacZ) mice exhibit severe T-cell deficiency and skeletal defects of various lineages, whereas a Zeb1 mutant allele obtained earlier, and that potentially could still produce a C-terminally truncated ZEB1 (but without CZF), showed only distorted composition of CD4 or CD8 expressing T-cells within the thymus and in peripheral lymph nodes [93,94].