The method of TaqMan-MGB real-time quantitative PCR we established to detect the level of RIG-G mRNA displayed a high sensitivity, with a minimum detection limit of 101 copies/μL, excellent stability and repeatability, as well as a wide linear detection range of up to 7 orders of magnitude (107~101 copies/μL) and was also not affected by high bilirubin and hyperlipidemia. The gene discussed is IFIT3; the disease is hyperlipidemia.