Mutations in the HSPD1 gene, encoding the protein HSP60, have been found in patients with hypomyelinating leukodystrophies like Pelizaeus–Merzbacher disease (p. D29G) [71,72], with hereditary spastic paraplegia (p. V72I) [73] or with familiar dilated cardiomyopathy (p.T320A) [74]. Here, HSPD1 is linked to dilated cardiomyopathy.