Additional studies found new mutations in MIC13 associated with mitochondrial encephalopathy (c.13_29del causing the frameshift p.W6Pfs*71, c.44delC causing the frameshift p.G15Efs*75, c.260-2A>G causing two aberrant splicing sites) [109,110,111]. Here, MICOS13 is linked to Mitochondrial encephalopathy.