NFKB1 and skin neoplasm: Grape seed proanthocyanidins (GSPs) affords to prevent the occurrence of UV radiation-induced skin cancers through scavenging free radicals, diminishing the depletion of antioxidant enzymes (e.g. GSH-Px, CAT, SOD), reducing lipid/protein oxidative damage and inactivating MAPK and NF-κB pathways [107, 108].