AKT1 and vitiligo: Other flavonoids like apigenin has a protective effect on dopamine-induced apoptosis of melanocytes; it protects melanocytes from OS insult via eliminating the accumulation of ROS and inhibiting the activation of OS-related pathways like JNK, p38 MAPK and Akt [83]; thus, apigenin may be considered as a potential candidate for the treatment of vitiligo, especially contact/occupational vitiligo.