On the AD models induced by dinitrochlorobenzene (DNCB) or lipopolysaccharide-stimulated RAW264.7 macrophages, likewise, quercetin and galangin were quite a useful to ameliorate the symptoms of AD in mice via curbing ERK1/2 and JNK pathways, downregulating iNOS activity and lessening NO production [138]. The gene discussed is MAPK3; the disease is Alzheimer disease.