In brief, owing to their abilities of scavenging free radicals, LPO and modulating multiple redox signaling pathways, such as NF-κB, JAK/STAT3, Nrf2, p38 MAPK, flavonoids are proposed as a prospective antioxidant and anti-psoriatic agent for psoriasis recovery through arresting OS damage. This evidence concerns the gene NFE2L2 and psoriasis.