Additionally, puerarin, one of main isoflavone compounds, efficiently lowered the levels of cytokines and chemokines in TNF-α/IFN-stimulated HaCaT cells, and inhibited the activation of MAPKs (p38, ERK and JNK) and NF-κB signal pathways as well as STAT-1 in AD models, furthther indicating the protection of puerarin on AD-like skin from inflammation and OS via mediating the phosphorylation of MAPKs, NF-κB and STAT-1 [143]. This evidence concerns the gene TNF and Alzheimer disease.