Baicalein, a kind of flavonoids, could strengthen melanocytic antioxidant defense, ameliorate mitochondrial dysfunction and mitigate cellular impairments in vitiligo via activating Nrf2 signaling pathway and enhancing HO-1 expression [89]; it, simultaneously, reduced intracellular ROS production in vitiligo skin and inhibited p38 MAPK pathway activation to stop OS invasion and protect melanocytes from oxidative damage [90]; therefore, baicalein would be promising for vitiligo. This evidence concerns the gene HMOX1 and vitiligo.