HMOX1 and vitiligo: Additionally, afzelin could not only prevent H2O2-induced apoptosis, LPO and ROS production in melanocytes, but also enhance the expression of Nrf2, HO-1 and CAT, therefore demonstrating that afzelin would be effective in the prevention of OS-induced melanocytes damage and the control of vitiligo through mediating Nrf2 pathway [88].