In brief, owing to their abilities of scavenging free radicals, LPO and modulating multiple redox signaling pathways, such as NF-κB, JAK/STAT3, Nrf2, p38 MAPK, flavonoids are proposed as a prospective antioxidant and anti-psoriatic agent for psoriasis recovery through arresting OS damage. The gene discussed is NFKB1; the disease is psoriasis.