Other flavonoids particularly delphinidin exhibits powerful anti-psoriatic effects in vivo and in vitro on a psoriasis-like model of Balb/c mice as well as a reconstructed psoriatic skin equivalent via PI3K/mTOR pathway; most notably, topical delphinidin distinctly decreased hyperproliferation and epidermal thickness [77, 78]. This evidence concerns the gene MTOR and psoriasis.