In addition, several experiments on psoriasis-like models have confirmed that flavonols (e.g. quercetin and astilbin) would be greatly potential to psoriasis healing via inhibiting Th17 cell differentiation, enhancing Nrf2 signal and blocking NF-κB or JAK/STAT3 pathways further to eliminate ROS and inflammation [75, 76]. Here, NFKB1 is linked to psoriasis.