Studies in vitro and in vivo revealed that topical application of ISO-1, an isoflavone extract from soybean, obviously alleviated DNCB-induced skin changes (e.g. erythema, trans-epidermal water loss, skin thickening and leukocyte infiltration) in DNCB-induced AD mice models, through modulation of the p38, JNK or NF-κB pathways and resistance to OS [141]. This evidence concerns the gene MAPK8 and Alzheimer disease.