The importance of glycogen and lipids in radiation response and cancer metabolism has been previously reported.12, , , –16,23 The insights on how glycogen and lipids (cholesterol, phosphatidylserine, and stearic acid) can be linked to PR/ER and Ki67 molecular histotypes and how this relates to RT are reported by RS for the first time to our knowledge, although these metabolites have been studied intensively in the cancer research community.56, , –59,63, , , , –68. The gene discussed is ESR1; the disease is cancer.