ENPP1 and arterial calcification, generalized, of infancy, 1: A genotypic and phenotypic overlap of GACI with pseudoxanthoma elasticum (PXE) has been reported.(7) Classic PXE is caused by ABCC6 variants, manifests as soon as the second decade of life with skin changes, and is characterized by mineralization and fragmentation of elastic fibers in skin, eyes, and cardiovascular system.(19, 20) There are case reports of individuals diagnosed with GACI due to ENPP1 variants who developed PXE‐like symptoms, which suggests that PXE‐like symptoms may not be limited to genotype but to a common mechanism of low PPi and ectopic calcification.(7)