In the PLAGL1:FOXO1 fusion observed here, the DNA binding domain of PLAGL1 is juxtaposed to the C-terminal TAD of FOXO1, which seems quite similar to PAX3:FOXO1 rearrangements as frequently observed in alveolar rhabdomyosarcoma [15]. This evidence concerns the gene FOXO1 and alveolar rhabdomyosarcoma.