Pattern B, which includes lung, melanoma, and pancreatic cancer, has a broader genome-wide significant signal overlapping both the TERT (chr5: 1,253,282–1,295,178 bp) and CLPTM1L genes (chr5: 1,317,869–1,345,180 bp) (Figure 3B). Here, TERT is linked to familial pancreatic carcinoma.