Meanwhile, the CLPTM1L gene encodes the cleft lip and palate-associated transmembrane-1 like protein, which has been reported to play a role in cell apoptosis and cytokinesis and is overexpressed in lung and pancreatic cancer.66, 67, 68 Given its important biological function and significant association with a broad set of cancers, we assumed that multiple variants in this region may independently influence the risk of various types of cancers. This evidence concerns the gene CLPTM1L and familial pancreatic carcinoma.