CLPTM1L and cancer: Meanwhile, the CLPTM1L gene encodes the cleft lip and palate-associated transmembrane-1 like protein, which has been reported to play a role in cell apoptosis and cytokinesis and is overexpressed in lung and pancreatic cancer.66, 67, 68 Given its important biological function and significant association with a broad set of cancers, we assumed that multiple variants in this region may independently influence the risk of various types of cancers.