Similar findings were also presented by a research on bone-cancer induced pain (BCP), showing that downregulation of ANXA3 using shRNA substantially inhibited the expression of HIF1α and VEGF in the ipsilateral spinal cord and microglial cells of mice undertaken 21 days of bone cancer induction (Zhang Z. et al., 2020). The gene discussed is ANXA3; the disease is bone neoplasm.