Another putative mechanism contributing to the pro-proliferative effect of ANXA3 was provided by the work of Wan et al., in which PI3K/Akt signaling pathway was found to be substantially inhibited in pancreatic cancer patients with overexpression of miR-382, a miRNA that suppresses the expression of the ANXA3 gene (Wan et al., 2020). Here, AKT1 is linked to familial pancreatic carcinoma.