This finding was further corroborated by another study on chemoresistant non-small cell lung cancer (NSCLC) cells, which showed that high level of ANXA3 secreted by cancer associated fibroblasts (CAFs) in the tumor microenvironment activated the JNK/survivin signaling, thereby helping cancer cells escaping the cisplatin-induced apoptosis (Wang et al., 2019). This evidence concerns the gene MAPK8 and cancer.