ANXA3 and renal cell carcinoma: It was speculated that the downregulation of the total ANXA3 protein in RCC was associated with the decrement of its 36-kDa isoform, as the N-terminus of ANXA3 capable of promoting self-expression is present in the 36-kDa isoform but absent in the 33-kDa isoform (Hofmann et al., 2000; Gerke et al., 2005; Bianchi et al., 2010).