Fluoropyrimidine resistance. The involvement of ANXA3 in 5-fluorouracil (5-FU) resistance has been previously reported in hepatocellular carcinoma, in which enforced ANXA3 expression established by ANXA3-overexpressing lentiviruses significantly enhanced the IC50 of 5-FU in both cell-line models and mouse xenografts models (Pan et al., 2015b). Here, ANXA3 is linked to hepatocellular carcinoma.